Statues of the Virgin Mary have been embarking on various types of movement and migration for centuries. They are the fixed points around which religious activities are carried out in communities in Spain and Latin America and play significant roles in the personal and social lives of their devotees. Until recently, however, scholarship has largely overlooked the potential richness of what religious material cultures can tell us about religious transformation in Latin America. This paper therefore offers a theoretical and methodological advance by way of a ground-up, ‘material’ approach to understanding religious change through the religious statues themselves. It utilises the statue of the Virgen de la Regla in Chipiona, Spain as a node on a map from which to trace the lines of movement from Spain into Cuba where a replica of the same Virgin, another nodal point, is worshipped as both Virgin Mary and Santeria Orisha Yamaya.