The Mexican city of Catemaco is famous for its diversity of African-American religious traditions. Although Santería was originally shaped in Cuba, the local Mexican versions show not only a variety of references regarding their origins and influences, ranging from West Africa and Cuba to local indigenous traditions, but also (re)interpretations of historically and geographically diverse contents. Based on interview data gathered during field research in 2017, this article outlines the different hybrid (re)configurations of African-Mexican Santería in Catemaco by tracing the changes made by the practitioners in order to adapt existing traditions. The corresponding adaptation processes include beliefs, practices, lore and material assets. Under a critical perspective, concepts of transnationalism, syncretism and glocalization are discussed, focussing on the dynamics between local and global aspects of Santería in Catemaco and shedding light on the processes of inclusion, exclusion and the shift of boundaries.