Over the past thirty years, relations between Russia and the EU have gone from the idea of a ‘Common European home’ and ‘the unification of everything except institutions’ to periods of fading partnership, culminating in the post-Crimean crisis and the current systemic confrontation over geopolitics and values. Today, the EU and Russia seem to be irreconcilable in terms of values, domestic politics, and geopolitical approaches. For the time being, the most likely scenario for EU-Russia relations will be tense coexistence with cooperation restricted by a climate of general mistrust. The best prospects for constructive cooperation will come from a common commitment to pragmatic ‘neighborliness’. Nevertheless, given the turbulence and unpredictability of international politics a return to “Greater European” integration cannot be entirely ruled out. The fundamental conditions for such a rapprochement still exist, though critical internal processes and external issues need to be resolved before this process can begin.